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Gene Expression Data
Assay Details
Assay
Reference: J:173463 Bejarano-Escobar R, et al., Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and D. Dev Dyn. 2011 Jul;240(7):1841-55
Assay type: RNA in situ
MGI Accession ID: MGI:5588135
Gene symbol: Ctsb
Gene name: cathepsin B
Probe: mCatB cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: optic cup Present Single cells Expression is in a few large rounded cells dispersed throughout the neural retina.
Specimen 1A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: intraretinal space Present Single cells 1C
TS18: lens vesicle Present Single cells 1C
TS18: retina Present Single cells 1C Expression is in the central retina dorsally to the optic stalk.
TS18: eye Present Single cells 1C Expression is in the mesenchyme between the cornea and the lens.
TS18: head mesenchyme Present Regionally restricted 1C Expression is in the mesenchymal tissue around the eye.
TS18: pigmented retinal epithelium Absent 1C
Specimen 1E: embryonic day 11.0 (more )
Note: F is a higher magnification of E.
Structure Level Pattern Image Note
TS18: retina Present Single cells 1F , 1E Expression is in the central retina dorsally to the optic stalk.
TS18: head mesenchyme Present Regionally restricted 1E Expression is in the mesenchymal tissue around the eye.
TS18: pigmented retinal epithelium Absent 1E , 1F
Specimen 2B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: retina Present Single cells 2B Expression is at the posterior pole.
TS20: pigmented retinal epithelium Absent 2B
Specimen 2C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: retina Present Single cells 2C Expression is at the posterior pole.
TS20: lens vesicle Present Single cells 2C
TS20: lens vesicle anterior epithelium Present Single cells 2C
Specimen 2E: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: hyaloid cavity Present Single cells 2E
TS21: lens anterior epithelium Present Single cells 2E
TS21: retina Present Single cells 2E
TS21: lens Present Single cells 2E Within the lens vesicle cavity.
TS21: pigmented retinal epithelium Absent 2E
Specimen 2F: embryonic day 13.5 (more )
Note: G is a higher magnification of F.
Structure Level Pattern Image Note
TS21: retina Present Single cells 2F , 2G Labeled cells in the fundus surround the optic nerve head.
TS21: pigmented retinal epithelium Absent 2F , 2G
Specimen 2K: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: retina Present Single cells 2K Mostly at the peripheral areas, near the ciliary margin.
Specimen 3I: postnatal day 12 (more )
Note: J is a higher magnification of I.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3J , 3I
TS28: sclera Present 3J , 3I
TS28: pigmented retinal epithelium Absent 3J , 3I
Specimen 4A: postnatal day 10 (more )
Note: Double labeled: purple - Ctsb; green - Glul (assay MGI:5588246).
Structure Level Pattern Image Note
TS28: retina Present Single cells 4A , 4C
Specimen 4G: postnatal day 2 (more )
Note: Triple labeled: purple - Ctsb; green - Isl1 (assay MGI:5588137); red - Calb2 (assay MGI:5588244).
Structure Level Pattern Image Note
TS27: retina Present Single cells 4G , 4J
TS27: pigmented retinal epithelium Absent 4G , 4J
Specimen 4N: postnatal day 10 (more )
Note: Double labeled with tomato lectin (green).
Structure Level Pattern Image Note
TS28: retina Present Single cells 4P , 4N
Specimen 5A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: optic stalk Present Regionally restricted 5A Expression is in the ventral region.
Specimen 5C: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: optic stalk Present Regionally restricted 5C Expression is in the ventral region.
Specimen 5E: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: optic nerve Present Single cells 5E Labeled cells almost disappeared at this age.
Specimen 5G: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: optic nerve Present Single cells 5G There were few labeled cells.
Specimen 5H: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: optic nerve Present Single cells 5H There were few labeled cells.
Specimen 5I: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: optic nerve Present Single cells 5I There were few labeled cells.
Specimen 5J: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: optic nerve Present Single cells 5J
Specimen 6A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: optic nerve Present Single cells 6A
Specimen 6B: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: optic nerve Present Single cells 6B
Specimen 6C: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: optic nerve Present Single cells 6C
Specimen 6F: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present Single cells 6F
Specimen 6G: postnatal day 15 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present Single cells 6G
Specimen 7A: embryonic day 12.0 (more )
Note: B is a higher magnification of A.
Structure Level Pattern Image Note
TS20: optic chiasma Present Single cells 7A , 7B
Specimen 7I: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: optic chiasma Present Single cells 7I
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory