Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Flt4tm2.1(cre/Esr1*)Ichi
Name:	FMS-like tyrosine kinase 4; targeted mutation 2.1, Hirotake Ichise
MGI ID:	MGI:5584320
Synonyms:	Vegfr3-CreMer
Gene:	Flt4  Location: Chr11:49500506-49543566 bp, + strand  Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
Alliance:	Flt4tm2.1(cre/Esr1*)Ichi page

Germline Transmission:	Earliest citation of germline transmission: J:212356
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6J x 129S/SvEv)F1

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Flt4tm2.1(cre/Esr1*)Ichi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Flt4 (MGI:95561)   Mutation details: The coding sequence in the first exon was replaced with a fusion of cre and tamoxifen-inducible cre recombinase (Cremer) followed by an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:212356)

Activity:	Tissue activity of this recombinase allele
Driver:	Flt4 (mouse) Summary of all recombinase alleles driven by Flt4. Comparative matrix view of recombinase activities Alliance mouse Flt4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt4 Mutation:	76 strains or lines available

Original:	J:212356 Ichise T, et al., FGF2-induced Ras-MAPK signalling maintains lymphatic endothelial cell identity by upregulating endothelial-cell-specific gene expression and suppressing TGFbeta signalling through Smad2. J Cell Sci. 2014 Feb 15;127(Pt 4):845-57
All:	1 reference(s)