Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Cryaa-cre,Tyr)37Mlr
Name:	transgene insertion 37, Mike Robinson
MGI ID:	MGI:5582797
Synonyms:	CPV2/Cre, MLR37
Transgene:	Tg(Cryaa-cre,Tyr)37Mlr  Location: unknown
Alliance:	Tg(Cryaa-cre,Tyr)37Mlr page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Cryaa-cre,Tyr)37Mlr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Cryaa (MGI:88515)   Mutation details: The mouse alpha A crystallin promoter (nucleotides -282 through +43 of the Cryaa gene) drives expression of the cre recombinase coding sequence, which is followed by the intron and polyadenylation signal of the mouse metallothionein 1 gene. Seven founder lines were generated using this construct, which in this line was coinjected with a tyrosinase minigene. In transgenic mice of this line also carrying Gt(ROSA)26Sortm1Sor, X-Gal staining for beta-galactosidase activity demonstrates low level cre recombinase expression in lens epithelium and higher level expression in lens fiber cells; ectopic ocular expression is observed in the retina, retinal pigmented epithelium (RPE) and cornea. (J:90292) Inheritance:    Dominant

Activity:	Tissue activity of this recombinase allele
Driver:	Cryaa (mouse) Summary of all recombinase alleles driven by Cryaa. Alliance mouse Cryaa gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:90292 Zhao H, et al., Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1930-9
All:	1 reference(s)