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Gene Expression Data
Assay Details
Assay
Reference: J:137167 Tennese AA, et al., Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons. Dev Dyn. 2008 Jul;237(7):1935-43
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5582737
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: anti-TH (AB1542)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 1B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cervico-thoracic ganglion Present 1B
TS24: superior cervical ganglion Present 1B
Specimen 1B': embryonic day 16.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS24: superior cervical ganglion Present 1B' The majority of of superior cervical ganglia are located more caudally and are reduced in number.
TS24: cervico-thoracic ganglion Present 1B'
Specimen 2B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: sympathetic ganglion Present 2B
Specimen 2B': embryonic day 11.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS19: sympathetic ganglion Present 2B' Expression is similar to wild-type in this mutant.
Specimen 2C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present 2C
Specimen 2C': embryonic day 12.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present 2C' Expression is similar in this mutant which exhibits reduced migration in a subset of neurons.
Specimen 4A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: peripheral nerve trunk Present 4A
TS24: superior cervical ganglion Present 4A
Specimen 4A': embryonic day 16.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS24: peripheral nerve trunk Present 4A' Expression is present but branching and extension of neurites is reduced.
TS24: superior cervical ganglion Present 4A' Expression is present but branching and extension of neurites is reduced.
Specimen 5A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cervico-thoracic ganglion Present 5A
TS26: sympathetic ganglion Present 5A
Specimen 5A': embryonic day 18.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS26: cervico-thoracic ganglion Present 5A' Expression in this mutant is the same as in wild-type embryos.
TS26: sympathetic ganglion Present 5A' Expression in this mutant is the same as in wild-type embryos.
Specimen 5B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: thoracic ganglion Present 5B
Specimen 5B': embryonic day 16.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS24: thoracic ganglion Present 5B'
Specimen 5C: embryonic day 18.5 (more )
Note: D and D' are higher magnifications of the insets in C and C' respectively.
Structure Level Pattern Image Note
TS26: celiac ganglion Present 5D , 5C
TS26: inferior cervical ganglion Present 5D , 5C
TS26: superior cervical ganglion Present 5D , 5C
Specimen 5C': embryonic day 18.5; Ndntm2Stw/Ndntm2Stw (more )
Note: D and D' are higher magnifications of the insets in C and C' respectively.
Structure Level Pattern Image Note
TS26: celiac ganglion Present Punctate 5C' , 5D' Expression is similar to wild-type, innervation was reduced.
TS26: inferior cervical ganglion Present Punctate 5C' , 5D' Expression is similar to wild-type, innervation was reduced.
TS26: superior cervical ganglion Present Punctate 5C' , 5D' Expression is similar to wild-type, innervation was reduced.
Specimen 5E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thoracic ganglion Present 5E
Specimen 5E': embryonic day 18.5; Ndntm2Stw/Ndntm2Stw (more )
Structure Level Pattern Image Note
TS26: thoracic ganglion Present Punctate 5E'
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory