Tg(Cryaa-TGFBR2*)550Ove
Transgene Detail
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| Symbol: |
Tg(Cryaa-TGFBR2*)550Ove |
| Name: |
transgene insertion 550, Paul Overbeek |
| MGI ID: |
MGI:5582729 |
| Synonyms: |
deltakTbetaRII, OVE550 |
| Transgene: |
Tg(Cryaa-TGFBR2*)550Ove Location: unknown
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| Alliance: |
Tg(Cryaa-TGFBR2*)550Ove page
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| Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Cryaa-TGFBR2*)550Ove expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TGFBR2 (7048) |
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Expresses a truncated form excluding the cytoplasmic kinase domain |
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Tg(Cryaa-TGFBR2*)550Ove expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Cryaa (MGI:88515) |
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Mutation details: A 940 bp cDNA fragment encoding the signal peptide, extracellular domain, transmembrane domain and part of the intracellular domain, excluding the cytoplasmic kinase domain, of human transforming growth factor, beta receptor II (TGFRB2) was cloned between the mouse alpha A crystallin promoter (nt -366 through +46 of the Cryaa gene) and the small t intron and early region polyadenylation signal of the SV40 virus. The truncated, kinase deficient protein is expressed in the eye lenses of transgenic mice.
(J:71882, J:213051)
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| Inheritance: |
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Dominant |
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:71882 de Iongh RU, et al., Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development. 2001 Oct;128(20):3995-4010 |
| All: |
3 reference(s) |
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Analysis Tools
