Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dnase1l3tm1Dkit
Name:	deoxyribonuclease 1-like 3; targeted mutation 1, Daisuke Kitamura
MGI ID:	MGI:5581508
Synonyms:	DNase gamma -
Gene:	Dnase1l3  Location: Chr14:14475014-14504586 bp, + strand  Genetic Position: Chr14, 4.67 cM, cytoband A1
Alliance:	Dnase1l3tm1Dkit page

Germline Transmission:	Earliest citation of germline transmission: J:211019
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced codon His160 in exon 5, which comprises the catalytic center of the endonuclease. An activity gel assay confirmed the absence of protein activity. (J:211019)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnase1l3 Mutation:	23 strains or lines available

Original:	J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223
All:	4 reference(s)