Tg(ACTA2-hir/CD4/SELP)#aAdor
Transgene Detail
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| Symbol: |
Tg(ACTA2-hir/CD4/SELP)#aAdor |
| Name: |
transgene insertion #a, Anthony Dorling |
| MGI ID: |
MGI:5578127 |
| Synonyms: |
alpha-Hir-Tg |
| Transgene: |
Tg(ACTA2-hir/CD4/SELP)#aAdor Location: unknown
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| Alliance: |
Tg(ACTA2-hir/CD4/SELP)#aAdor page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(ACTA2-hir/CD4/SELP)#aAdor expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CD4 (920) |
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Transgene codes for a fusion protein of leech hirudin and human CD4 and SELP. |
| human |
SELP (6403) |
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Transgene codes for a fusion protein of leech hirudin and human CD4 and SELP. |
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Mutation details: The human promoter drives expression of the fusion of leech hirudin, domains 3 and 4 of human CD4 domain and intracytoplasmic sequence of human SELP in smooth muscle cells. Four lines were generated. The unnamed line (#a) contains greater than 30 copies of the transgene.
(J:135627)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:135627 Chen D, et al., Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. J Thromb Haemost. 2006 Oct;4(10):2191-8 |
| All: |
1 reference(s) |
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Analysis Tools
