Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Scgb1a1-TFRC/OVA)1Adl
Name:	transgene insetion 1, Andrew D Luster
MGI ID:	MGI:5575977
Synonyms:	CC10-OVA
Transgene:	Tg(Scgb1a1-TFRC/OVA)1Adl  Location: unknown
Alliance:	Tg(Scgb1a1-TFRC/OVA)1Adl page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Scgb1a1-TFRC/OVA)1Adl expresses 1 gene Transgene expresses: Organism Expressed Gene Note chicken OVAL (396058)   Mutation details: The CC10-OVA transgene was designed with a 2.4 kbp promoter from rat Clara cell secretory protein (CC10 or Scgb1a1), a DNA sequence encoding the transmembrane domain (residues 2-118) of the human transferrin receptor (CD71 or TFRC) fused to a DNA sequence encoding amino acids 139-385 of mature chicken ovalbumin (the p139-387 segment including the p257-264 [SIINFEKL] and p323-339 epitopes recognized by OT-I and OT-II TCR transgenic cells, respectively). The founder mouse line with the highest copy number (at least three copies) was identified and used. (J:100652)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:100652 Medoff BD, et al., BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med. 2005 Jul 4;202(1):97-110
All:	1 reference(s)