Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Phox2btm1Rth
Name:	paired-like homeobox 2b; targeted mutation 1, David H Rowitch
MGI ID:	MGI:5575410
Gene:	Phox2b  Location: Chr5:67251740-67256469 bp, - strand  Genetic Position: Chr5, 35.95 cM
Alliance:	Phox2btm1Rth page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Humanized sequence, Reporter) Mutation:    Insertion   Mutation details: Exon 3 of the mouse Phox2b gene was flanked by loxP sites. An FRT-flanked neomycin cassette, human exon 3 (modified with an 8 bp deletion, GGCCCGGG) and associated with an EGFP reporter, was inserted downstream. Flp-mediated recombination removed the selection cassette. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Phox2b Mutation:	25 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	4 reference(s)