Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Stat3*)9199Alau
Name:	transgene insertion 9199, Arian Laurence
MGI ID:	MGI:5574060
Synonyms:	mut-Stat3, Stat3-deltaV463, Tg(Stat3*)L1Alau
Transgene:	Tg(Stat3*)9199Alau  Location: unknown
Alliance:	Tg(Stat3*)9199Alau page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Stat3*)9199Alau expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Stat3 (MGI:103038)   Mutation details: This transgene consists of a bacterial artificial chromosome (RP24-236G5 BAC) containing mouse Stat3 that was modified to delete valine 463 from the binding domain. The deletion consists of a 1,163 bp DNA fragment starting with the last codon of Stat3 exon 15 and ending at the 5' end of exon 16. This mutation affects Stat3 DNA binding activity in a dominant negative way. Line 9199 (L1) contains 2 transgene copies. (J:210877)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:210877 Steward-Tharp SM, et al., A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood. 2014 May 8;123(19):2978-87
All:	8 reference(s)