Tg(Aire-cre/Esr1)1Mmat
Transgene Detail
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| Symbol: |
Tg(Aire-cre/Esr1)1Mmat |
| Name: |
transgene insertion 1, Mitsuru Matsumoto |
| MGI ID: |
MGI:5570119 |
| Synonyms: |
Aire/CreER BAC tg, Tg(Aire-cre/ERT2)1Mmat |
| Transgene: |
Tg(Aire-cre/Esr1)1Mmat Location: unknown
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| Alliance: |
Tg(Aire-cre/Esr1)1Mmat page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Aire-cre/Esr1)1Mmat expression driven by
1 gene
Transgene expression driven by:
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Mutation details: A targeting vector was constructed from a BAC (RP23-461E7) containing the entire Aire gene by replacing the Aire start codon with the open reading frame of a cre/Esr1 (originally reported as ERT2) fusion sequence and the polyA signal of rabbit beta-globin. The linearized BAC construct was microinjected into C57BL/6 fertilized pronuclei and founders were identified by Southern blot analysis. One line was established and crossed to reporter mouse lines for further analyses.
(J:209922)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Aire
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:209922 Nishikawa Y, et al., Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program. J Immunol. 2014 Mar 15;192(6):2585-92 |
| All: |
1 reference(s) |
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Analysis Tools
