Thtm1.1(cre/ERT2)Ddg
Targeted Allele Detail
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Symbol: |
Thtm1.1(cre/ERT2)Ddg |
Name: |
tyrosine hydroxylase; targeted mutation 1.1, David Ginty |
MGI ID: |
MGI:5569743 |
Synonyms: |
TH2A-CreER |
Gene: |
Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
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Alliance: |
Thtm1.1(cre/ERT2)Ddg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:239228
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Thtm1.1(cre/ERT2)Ddg expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Th (MGI:98735) |
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Mutation details: A T2A cleavage peptide and the cre/ERT2 fusion protein-coding sequence were introduced to the 3'UTR of the mouse Th gene. An FRT-PGK-EM7-NEOpolyA-FRT-loxP cassette was placed downstream of the 3'UTR region. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette.
(J:239228)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Th
(mouse)
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Original: |
J:239228 Abraira VE, et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12;168(1-2):295-310.e19 |
All: |
13 reference(s) |
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