Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Igh-R4AVh/Ighma)1Dmnd
Name:	transgene insertion 1, Betty Diamond
MGI ID:	MGI:5569385
Synonyms:	R4A-Cmu, R4A-Cu
Transgene:	Tg(Igh-R4AVh/Ighma)1Dmnd  Location: unknown
Alliance:	Tg(Igh-R4AVh/Ighma)1Dmnd page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Igh-R4AVh/Ighma)1Dmnd expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ighm (MGI:96448)   Mutation details: This transgene contains the unmutated, rearranged immunoglobulin V-D-J and heavy chain enhancer region from the anti-dsDNA producing hybridoma R4A, comprising the S107 V11 heavy chain gene and a Vk1 light chain gene, ligated to a 9.9 kb fragment from all (membrane and secreted) the exons of the Igh-mu constant region (Cu) from BALB/c, which is of the Ighma allotype. Southern blot analysis indicates that the transgene integrated in a single site of the genome. There are 5 copies of the transgene. (J:73871)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:73871 Chu YP, et al., Persistence of partially functional double-stranded (ds) DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody. Int Immunol. 2002 Jan;14(1):45-54
All:	1 reference(s)