Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Camk2a-P2rx2/YC3.1)21Khakh
Name:	transgene insertion 21, Baljit Khakh
MGI ID:	MGI:5569123
Synonyms:	SPRAE
Transgene:	Tg(Camk2a-P2rx2/YC3.1)21Khakh  Location: unknown
Alliance:	Tg(Camk2a-P2rx2/YC3.1)21Khakh page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inserted expressed sequence, Reporter) Mutation:    Insertion   Tg(Camk2a-P2rx2/YC3.1)21Khakh expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note rat P2rx2 (114115) P2rx2  (MGI:2665170)   Mutation details: The transgene contains the entire Ca2+/calmodulin-dependent protein kinase II alpha locus, ~110 kbp 5' flanking region (including the Arsi locus and a portion of the Tcof1 locus) and ~50 kbp 3' flanking region (including the Slc6a7 and Cdx1 loci) from BAC RP23-221H5. The P2X2-YC3.1 fusion gene was inserted immediately upstream of the CaMKIIalpha translation initiation codon in exon 1 via homologous recombination/BAC recombineering. The P2rx2/YC3.1 fusion gene encodes rat P2rx2 fused at its carboxy terminus to the fluorescence resonance energy transfer (FRET)-based optical reporter Yellow Cameleon 3.1 (YC3.1). (J:209943)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:209943 Haustein MD, et al., Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron. 2014 Apr 16;82(2):413-29
All:	1 reference(s)