Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pfn1tm2.1(GFP/ACTB)Wit
Name:	profilin 1; targeted mutation 2.1, Walter Witke
MGI ID:	MGI:5568700
Synonyms:	huGE
Gene:	Pfn1  Location: Chr11:70542676-70545470 bp, - strand  Genetic Position: Chr11, 43.21 cM, cytoband A-D
Alliance:	Pfn1tm2.1(GFP/ACTB)Wit page

Germline Transmission:	Earliest citation of germline transmission: J:209786
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A GFP cDNA was fused to the 5' end of the human cDNA with a bovine growth hormone polyadenylation sequence. This fusion construct was inserted at the translation initiation site. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:209786)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfn1 Mutation:	10 strains or lines available

Original:	J:209786 Gurniak CB, et al., HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics. Eur J Cell Biol. 2007 Jan;86(1):3-12
All:	3 reference(s)