Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlr4tm1.1Karp
Name:	toll-like receptor 4; targeted mutation 1.1, Christopher Karp
MGI ID:	MGI:5568597
Synonyms:	TLR4fl
Gene:	Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4tm1.1Karp page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	CMTI-2 (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A targeting vector containing a FRT site flanked neomycin selection cassette and a loxP site was inserted downstream of exon 3 of the targeted gene, and another loxP site was inserted upstream of exon 3. Mutant mice were bred with ACT-FLPe mice (on a C57BL/6 congenic background) to remove the neomycin selection cassette. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	90 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	24 reference(s)