Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Grb2tm1.1Lnit
Name:	growth factor receptor bound protein 2; targeted mutation 1.1, Lars Nitschke
MGI ID:	MGI:5568397
Synonyms:	Grb2fl
Gene:	Grb2  Location: Chr11:115534871-115599423 bp, - strand  Genetic Position: Chr11, 80.91 cM
Alliance:	Grb2tm1.1Lnit page

Germline Transmission:	Earliest citation of germline transmission: J:171222
Parent Cell Line:	BALB/c-I (ES Cell)
Strain of Origin:	BALB/cJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. FLP-mediated recombination removed the FRT-flanked neo cassette. (J:101977, J:171222)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:	42 strains or lines available

Original:	J:171222 Ackermann JA, et al., Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca(2+) signalling. EMBO J. 2011 Apr 20;30(8):1621-33
All:	6 reference(s)