Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Gata1-icre)1Jtp
Name:	transgene insertion 1, Josef T Prchal
MGI ID:	MGI:5568218
Synonyms:	Gata-1-HRD-iCre
Transgene:	Tg(Gata1-icre)1Jtp  Location: unknown
Alliance:	Tg(Gata1-icre)1Jtp page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Gata1-icre)1Jtp expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Gata1   Mutation details: A construct was generated by inserting the icre (improved cre) cDNA between the promoter region and polyA site in the IE3.9intpolyAA construct (containg the Gata1-HRD promoter (HRD; hematopoietic regulatory domain)). The transgenic vector was verified by sequencing, linearized and used for pronuclear injection. Three transgenic founders were identified from 16 chimeras, and cre activity was assessed in progeny of crossed to ROSA26 reporter animals. Reporter activation was detected only in bone marrow cells (in early erythroid progenitors) and not in any other organ or tissue examined. The line with greatest cre activity was selected for further analyses. (J:209268)

Activity:	Tissue activity of this recombinase allele
Driver:	Gata1 (species not specified) Summary of all recombinase alleles driven by Gata1. Comparative matrix view of recombinase activities

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:209268 Yoon D, et al., Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific. Blood Cells Mol Dis. 2008 May-Jun;40(3):381-7
All:	1 reference(s)