Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Lrrk1tm1.1Smo
Name:	leucine-rich repeat kinase 1; targeted mutation 1.1, Subburaman Mohan
MGI ID:	MGI:5568128
Gene:	Lrrk1  Location: Chr7:65908493-66038089 bp, - strand  Genetic Position: Chr7, 35.57 cM
Alliance:	Lrrk1tm1.1Smo page

Germline Transmission:	Earliest citation of germline transmission: J:208677
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin resistance cassette replaced exons 16 through 19 (numbered according to accession NM_146191.3). Cre-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in osteoclasts and bone marrow stromal cells. (J:208677)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrk1 Mutation:	76 strains or lines available

Original:	J:208677 Xing W, et al., Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. J Bone Miner Res. 2013 Sep;28(9):1962-74
All:	2 reference(s)