Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Flt3tm1.1Dosm
Name:	FMS-like tyrosine kinase 3; targeted mutation 1.1, Donald Small
MGI ID:	MGI:5565508
Synonyms:	FLT3/ITD
Gene:	Flt3  Location: Chr5:147267551-147337299 bp, - strand  Genetic Position: Chr5, 86.88 cM, cytoband G3
Alliance:	Flt3tm1.1Dosm page

Germline Transmission:	Earliest citation of germline transmission: J:205200
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Constitutively active) Mutations:    Insertion, Single point mutation   Mutation details: Exon 14 was replaced with an exon 14 into which the internal tandem duplication (ITD) AGGACTGATTTCAGCGAA from a patient with acute myeloid leukemia was inserted. A floxed neo cassette was placed downstream of exon 15. Cre mediated recombination removed the neo cassette. (J:133528)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt3 Mutation:	83 strains or lines available

Original:	J:205200 Bailey E, et al., FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21113-8
All:	6 reference(s)