Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Adcyap1tm1.1(cre)Mjkr
Name:	adenylate cyclase activating polypeptide 1; targeted mutation 1.1, Michael J Krashes
MGI ID:	MGI:5562871
Synonyms:	Pacap-IRES-Cre
Gene:	Adcyap1  Location: Chr17:93506448-93513967 bp, + strand  Genetic Position: Chr17, 60.67 cM
Alliance:	Adcyap1tm1.1(cre)Mjkr page

Germline Transmission:	Earliest citation of germline transmission: J:207472
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Adcyap1tm1.1(cre)Mjkr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Adcyap1 (MGI:105094)   Mutation details: Using recombineering methods, a selection cassette containing an internal ribosomal entry sequence (IRES) linked to cre and an frt-flanked kanamycin gene was inserted immediately downstream of the stop codon in exon 5 of the Adcyap1 gene in a BAC. This construct was used to isolate a targeting plasmid with the cre-kanamycin cassette with upstream and downstream Adcyap1 homology arms. ES cells were targeted and used for blastocyst injection. Chimeras were bred for germline transmission. The selection marker was excised by breeding to Flp deleter animals. (J:207472)

Activity:	Tissue activity of this recombinase allele
Driver:	Adcyap1 (mouse) Summary of all recombinase alleles driven by Adcyap1. Comparative matrix view of recombinase activities Alliance mouse Adcyap1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:	22 strains or lines available

Original:	J:207472 Krashes MJ, et al., An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42
All:	8 reference(s)