Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Tmc2/AcGFP)3Ajg
Name:	transgene insertion 3, Andrew Griffith
MGI ID:	MGI:5560295
Synonyms:	Tg(RP24-293G8/Tmc2/AcGFP)3Ajg, Tmc2-AcGFP
Transgene:	Tg(Tmc2/AcGFP)3Ajg  Location: unknown
Alliance:	Tg(Tmc2/AcGFP)3Ajg page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Inserted expressed sequence, Reporter) Mutation:    Insertion   Tg(Tmc2/AcGFP)3Ajg expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Tmc2 (MGI:2151017)   Mutation details: The transgene was created by targeted insertion of Aequorea coerulescens green fluorescent protein (AcGFP) coding sequence into the bacterial artificial chromosome (BAC) RP24-293G8. The AcGFP sequence integrated at the stop codon of Tmc2. The integration site was not investigated. The C-terminal fusion is expressed in the sensory hair cells of the inner ear. The modified BAC also carries the Snrpb, Nop56, and Idh3b genes. Line 3 carries 3 copies of the transgene. (J:226895)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:226895 Kurima K, et al., TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Rep. 2015 Sep 8;12(10):1606-17
All:	2 reference(s)