Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-APPSweAut)A7Tiwa
Name:	transgene insertion A7, Takeshi Iwatsubo
MGI ID:	MGI:5559448
Synonyms:	A7 APP Tg, Tg(Thy1-APP*K670N*M671L*T714I)A7Tiwa, Tg(Thy1-APP*Swe*Aut)A7Tiwa
Transgene:	Tg(Thy1-APPSweAut)A7Tiwa  Location: unknown
Alliance:	Tg(Thy1-APPSweAut)A7Tiwa page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Thy1-APPSweAut)A7Tiwa expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human APP (351) App  (MGI:88059) The gene encodes for the Swedish and Austrian mutations.   Mutation details: This transgene expresses the human APP695 harboring the Swedish K670N and M671L (Swe) and the Austrian T714I (Aut) familial Alzheimer disease mutations in neurons under the control of the Thy1.2 promoter. Immunoblotting shows that expression of transgenic human APP proteins is about 1.4 fold that of endogenous murine App. (J:204270)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:204270 Yamada K, et al., Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. J Neurosci. 2009 Sep 9;29(36):11393-8
All:	7 reference(s)