Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wdpcpcys40
Name:	WD repeat containing planar cell polarity effector; cys40
MGI ID:	MGI:5558098
Synonyms:	Cys40, Wdpcpm
Gene:	Wdpcp  Location: Chr11:21521969-21848686 bp, + strand  Genetic Position: Chr11, 13.9 cM
Alliance:	Wdpcpcys40 page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: An A to G substitution was detected at nucleotide 224 of the mRNA, corresponding to the 8th base before the splice donor site of exon 5, resulting in a premature stop codon (S54X) after amino acid 54. Homozygous MEFs showed loss of protein immunostaining indicating this is a null allele. (J:94456, J:205269) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdpcp Mutation:	33 strains or lines available

Original:	J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All:	4 reference(s)