Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ddx4tm1.1(cre)Dcp
Name:	DEAD box helicase 4; targeted mutation 1.1, David C Page
MGI ID:	MGI:5554579
Synonyms:	Ddx4tm1.1(cre/mOrange)Dcp, MvhCre-mOrange
Gene:	Ddx4  Location: Chr13:112734867-112789009 bp, - strand  Genetic Position: Chr13, 63.87 cM
Alliance:	Ddx4tm1.1(cre)Dcp page

Germline Transmission:	Earliest citation of germline transmission: J:198777
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Ddx4tm1.1(cre)Dcp expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ddx4 (MGI:102670)   Mutation details: The sequence encoding a cre-mOrange fusion protein was inserted into the Ddx4 (Mvh) locus by homologous recombination with a targeting vector in ES cells. Part of exon 1 and intron 1 were replaced by the cre-mOrange sequence. A PGK-neo selection marker was inserted in the initial targeting, and was later removed by mating with FLPe-expressing mice. The mOrange fluorescent reporter in the construct does not appear to be functional. (J:198777)

Generation of Ddx4tm1.1(cre)Dcp

Activity:	Tissue activity of this recombinase allele
Driver:	Ddx4 (mouse) Summary of all recombinase alleles driven by Ddx4. Comparative matrix view of recombinase activities Alliance mouse Ddx4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddx4 Mutation:	58 strains or lines available

Original:	J:198777 Hu YC, et al., Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12685-90
All:	11 reference(s)