Gt(ROSA)26Sortm7(cre/ESR1)Arte
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm7(cre/ESR1)Arte |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 7, TaconicArtemis |
MGI ID: |
MGI:5551325 |
Synonyms: |
Gt(ROSA)26Sortm1(cre/ESR1)Arte, Rosa26::CreERT2, rosa(CreERT2) |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm7(cre/ESR1)Arte page
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm7(cre/ESR1)Arte expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Gt(ROSA)26Sor (MGI:104735) |
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Mutation details: A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. Following oral administration of tamoxifen recombination efficiency varies from up to 50% to almost 100% depending on the target allele and tissue. Recombination was lowest in the brain.
(J:126518)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Gt(ROSA)26Sor
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
944 strains or lines available
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Original: |
J:126518 Seibler J, et al., Rapid generation of inducible mouse mutants. Nucleic Acids Res. 2003 Feb 15;31(4):e12 |
All: |
11 reference(s) |
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