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Gene Expression Data
Assay Details
Assay
Reference: J:144407 Vong L, et al., MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev Dyn. 2006 Jul;235(7):1809-21
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5550499
Gene symbol: Hand1
Gene name: heart and neural crest derivatives expressed 1
Reporter: lacZ
Direct Detection
Results
Specimen not shown: embryonic day 8.0; Hand1tm1Cse/Hand1+ (more )
Note: 6 somite pairs.
Structure Level Pattern Image Note
TS12: primitive heart tube Present Expression is in the posterior-ventral surface of the linear heart.
Specimen 3A: embryonic day 8.0; Hand1tm1Cse/Hand1+ (more )
Note: 8 somite pairs.
Structure Level Pattern Image Note
TS12: primitive ventricle Present Regionally restricted 3A Expression is in the left ventral part of the left ventricle extending through the outer curvature of the atrioventricular canal.
TS12: common atrial chamber Present Regionally restricted 3A
TS12: outflow tract Present 3A
Specimen 3B: embryonic day 8.5; Hand1tm1Cse/Hand1+ (more )
Note: 10 somite pairs.
Structure Level Pattern Image Note
TS13: outflow tract Present 3B
TS13: primitive ventricle Present 3B
Specimen 3C: embryonic day 9.5; Hand1tm1Cse/Hand1+ (more )
Structure Level Pattern Image Note
TS15: heart atrium Present Regionally restricted 3C
TS15: primitive ventricle Present 3C Expression is in the outer curvature of the left ventricle.
Specimen 3D: embryonic day 8.0; Hand1tm1Cse/Hand1+, Mef2ctm1Eno/Mef2ctm1Eno (more )
Note: 8 somite pairs.
Structure Level Pattern Image Note
TS12: primitive ventricle Weak Regionally restricted 3D Expression is on the ventral surface of a small, linear ventricle.
TS12: outflow tract Present 3D Expression in this tissue was relatively normal.
Specimen 3E: embryonic day 8.5; Hand1tm1Cse/Hand1+, Mef2ctm1Eno/Mef2ctm1Eno (more )
Note: 10 somite pairs.
Structure Level Pattern Image Note
TS13: primitive ventricle Strong Regionally restricted 3E Expression is stronger in the posterior, ventral surface of the ventricle.
TS13: outflow tract Present 3E
Specimen 3F: embryonic day 9.5; Hand1tm1Cse/Hand1+, Mef2ctm1Eno/Mef2ctm1Eno (more )
Structure Level Pattern Image Note
TS15: heart atrium Weak 3F Ectopic expression on the dorsal surface of the right atrium.
TS15: primitive ventricle Weak 3F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory