Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Ucp1-cre)1Evdr
Name:	transgene insertion 1, Evan Rosen
MGI ID:	MGI:5550468
Transgene:	Tg(Ucp1-cre)1Evdr  Location: unknown
Alliance:	Tg(Ucp1-cre)1Evdr page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Ucp1-cre)1Evdr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Ucp1 (MGI:98894)   Mutation details: The C57BL/6 mouse bacterial artificial chromosome (BAC) 148M1 containing the entire Ucp1 gene, and other genes, was modified by inserting sequence encoding cre recombinase, into the translation initiation site into exon 1 of the Ucp1 gene. An FRT site flanked KAN cassette and a loxP site were removed. DNA from the modified BAC clone was used as the source for the transgene, which was microinjected into the pronucleus of FVB fertilized eggs. A founder line was subsequently established. (J:206508, J:214637)

Activity:	Tissue activity of this recombinase allele
Driver:	Ucp1 (mouse) Summary of all recombinase alleles driven by Ucp1. Comparative matrix view of recombinase activities Alliance mouse Ucp1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:214637 Kong X, et al., IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Cell. 2014 Jul 3;158(1):69-83
All:	91 reference(s)