Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(ACTA1-STIM1)2Jmol
Name:	transgene insertion 2, Jeffery Molkentin
MGI ID:	MGI:5550399
Transgene:	Tg(ACTA1-STIM1)2Jmol  Location: unknown  Genetic Position: ChrY, Syntenic
Alliance:	Tg(ACTA1-STIM1)2Jmol page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(ACTA1-STIM1)2Jmol expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human STIM1 (6786) Stim1  (MGI:107476)   Mutation details: The human STIM1 cDNA encoding the shorter spliced form was cloned into a human ACTA1 promoter (modified with a troponin 1 element to enhance expression in slow fibers) to create a skeletal muscle-specific transgenic strain. Expression is increased approximately 6-fold in the quadriceps, and at uniformly high levels in a broad range of skeletal muscle groups. No expression is observed in the heart. The transgene is integrated on the Y chromosome in this "low expressor" line. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	3 reference(s)