Marveld2tm1.1Sria
Targeted Allele Detail
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| Symbol: |
Marveld2tm1.1Sria |
| Name: |
MARVEL (membrane-associating) domain containing 2; targeted mutation 1.1, Saima Riazuddin |
| MGI ID: |
MGI:5550095 |
| Synonyms: |
TricR497X |
| Gene: |
Marveld2 Location: Chr13:100732465-100753479 bp, - strand Genetic Position: Chr13, 53.23 cM
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| Alliance: |
Marveld2tm1.1Sria page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:201580
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Humanized sequence, Modified isoform(s)) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An FRT flanked neo cassette and loxP site were inserted in front of exon 5, an R497X mutation was inserted in exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. RT-PCR analysis indicates an upregulation of the Marveld2-d (lacking exon 4) and Marveld2-e (alternative splice of exon 6) splice variants in the inner ear of homozygous mice at P10. Western blot analysis failed to detect wild-type protein in inner ear lysates from P10 homozygous mice.
(J:201580)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Marveld2 Mutation: |
29 strains or lines available
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| Original: |
J:201580 Nayak G, et al., Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest. 2013 Sep 3;123(9):4036-49 |
| All: |
1 reference(s) |
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Analysis Tools
