Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(MS4A1-cre/ERT2)1Mjsk
Name:	transgene insertion 1, Mark J Shlomchik
MGI ID:	MGI:5545930
Synonyms:	hCD20-TamCre, hCD20TamCre
Transgene:	Tg(MS4A1-cre/ERT2)1Mjsk  Location: unknown
Alliance:	Tg(MS4A1-cre/ERT2)1Mjsk page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(MS4A1-cre/ERT2)1Mjsk expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human MS4A1 (931) Ms4a1  (MGI:88321)   Mutation details: A BAC (RP11-729B4) containing the human MS4A1 (hCD20) locus was modified by insertion of an IRES-cre/ERT2 (cre recombinase-mutated human estrogen receptor ligand-binding domain fusion) cassette into the 3' untranslated region of the gene. The modified BAC vector was used to generate a transgene that expresses a tamoxifen-inducible cre specifically in B cells. MS4A1 is also expressed from this allele. Line numbers are not available. (J:184524)

Activity:	Tissue activity of this recombinase allele
Driver:	MS4A1 (human) Summary of all recombinase alleles driven by MS4A1. Alliance human MS4A1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:184524 Khalil AM, et al., B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012 Jun 1;336(6085):1178-81
All:	19 reference(s)