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Gene Expression Data
Assay Details
Assay
Reference: J:102270 Conte I, et al., Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain. Dev Dyn. 2005 Nov;234(3):718-25
Assay type: RNA in situ
MGI Accession ID: MGI:5545781
Gene symbol: Six3
Gene name: sine oculis-related homeobox 3
Probe: Six3 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Assay notes: Vibratome sections.
Results
Specimen 2a: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted 2a Expression is in the developing septum, bed nucleus of the stria terminalis, and caudate putamen.
Specimen 2c: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forebrain Present Regionally restricted 2c Expression is in the basal plate of the prosencephalon.
TS22: hypothalamus Present Regionally restricted 2c Expression is in the anterior hypothalamic area, in the medial preoptic area, the ventral suprachiasmatic nucleus, and the dorsomedial and ventromedial hypothalamic regions.
Specimen 2e: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forebrain Present Regionally restricted 2e Expression is in the basal plate of the prosencephalon.
TS22: hypothalamus Present Regionally restricted 2e Expression is in the anterior hypothalamic area, in the medial preoptic area, the ventral suprachiasmatic nucleus, and the dorsomedial and ventromedial hypothalamic regions.
Specimen 2g: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forebrain Present Regionally restricted 2g Expression is in the basal plate of the prosencephalon.
TS22: hypothalamus Present Regionally restricted 2g Expression is in the anterior hypothalamic area, in the medial preoptic area, the ventral suprachiasmatic nucleus, and the dorsomedial and ventromedial hypothalamic regions.
TS22: thalamus Present Regionally restricted 2g Expression is ventral.
Specimen not shown E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: diencephalon Present Regionally restricted in the caudal Expression is in a portion of the zona limitans, including the pretectal nuclei of the posterior commissure and the mesencephalic tegmentum.
Specimen 3a: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: hypothalamus Strong Regionally restricted 3a Expression is in the more dorsally located anterior hypothalamic area and the subincertal nucleus.
TS25: zona incerta Present 3a
TS25: thalamus Present Regionally restricted 3a Expression in the reticular thalamic nucleus.
TS25: cerebral cortex Present 3a
Specimen 3c: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: hypothalamus Strong Regionally restricted 3c Expression is in the more dorsally located anterior hypothalamic area and the subincertal nucleus.
TS25: thalamus Present Regionally restricted 3c Expression in the reticular thalamic nucleus.
TS25: cerebral cortex Present 3c
TS25: hippocampus Present 3c
Specimen 3e: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: thalamus Present Regionally restricted 3e Expression is in the anterior and posterior thalamus.
TS27: reticular thalamic nucleus Present 3e
TS27: zona incerta Present 3e
TS27: medial habenular nucleus Present 3e
Specimen 3g: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: thalamus Present Regionally restricted 3g Expression is in the anterior and posterior thalamus.
TS27: medial habenular nucleus Present 3g
TS27: reticular thalamic nucleus Present 3g
TS27: zona incerta Present 3g
Specimen 4a: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: main olfactory bulb Present Regionally restricted 4a Expression is in the mitral cell layer.
Specimen 4b: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: main olfactory bulb mitral cell layer Present 4b
Specimen 4c: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb mitral cell layer Present 4c
Specimen 4d: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: telencephalon septum Present Regionally restricted 4d Expression is in the triangular septal nucleus.
TS25: caudate-putamen Present 4d
Specimen 4e: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: midbrain Present Regionally restricted 4e Expression is in the substantia nigra.
TS25: midbrain tegmentum Present Regionally restricted 4e Expression is ventral.
Specimen 4f: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: midbrain Present Regionally restricted 4f Expression is in the inferior colliculus.
Specimen 4g: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: septal nucleus Strong Regionally restricted 4g Expression is in the triangular septal nucleus.
TS27: hippocampus CA2 Strong 4g
TS27: subfornical organ Strong 4g
TS27: cerebral cortex Present Regionally restricted 4g Expression is in the subplate.
TS27: bed nucleus of stria terminalis Present 4g
TS27: caudate-putamen Present 4g
TS27: hippocampus Present 4g
TS27: olfactory tubercle Present 4g
TS27: piriform cortex Present 4g
TS27: substantia nigra Present 4g
TS27: ventral tegmental area Present 4g
Specimen 4h: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: inferior colliculus Present 4h
TS27: substantia nigra Present 4h
TS27: ventral tegmental area Present 4h
Specimen 4i: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: inferior colliculus Present Regionally restricted 4i
TS27: cerebellar hemisphere Present 4i
TS27: cerebellum vermis Present 4i
TS27: facial nucleus Present 4i
TS27: locus coeruleus Present 4i
TS27: medial vestibular nucleus Present 4i
Specimen not shown E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: diencephalon Present Regionally restricted Expression is in the pretectal nuclei of the posterior commissure.
Specimen not showm P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: periaqueductal grey Present Regionally restricted Expression is in the ventral periaqueductal area.
TS27: deep cerebellar nucleus Present
TS27: red nucleus Present
Specimen 5a: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: brain Present Single cells 5a inset , 5a Expression is scattered throughout the brain.
TS28: bed nucleus of stria terminalis Present 5a
TS28: caudate-putamen Present 5a
TS28: dentate gyrus Present 5a
TS28: hippocampus CA1 Present 5a
TS28: hippocampus CA2 Present 5a
TS28: medial habenular nucleus Present 5a
TS28: reticular thalamic nucleus Present 5a
TS28: zona incerta Present 5a
TS28: hypothalamus Weak 5a
Specimen 5c: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: brain Present 5c , 5c inset Expression is scattered throughout the brain.
TS28: bed nucleus of stria terminalis Present 5c
TS28: caudate-putamen Present 5c
TS28: dentate gyrus Present 5c
TS28: hippocampus CA1 Present 5c
TS28: hippocampus CA2 Present 5c
TS28: medial habenular nucleus Present 5c
TS28: reticular thalamic nucleus Present 5c
TS28: zona incerta Present 5c
TS28: hypothalamus Weak 5c
Specimen 5e: postnatal day 40 (more )
Structure Level Pattern Image Note
TS28: medial habenular nucleus Strong 5e
TS28: bed nucleus of stria terminalis Present 5e , 5e inset
TS28: caudate-putamen Present 5e , 5e inset
TS28: reticular thalamic nucleus Present 5e , 5e inset
TS28: zona incerta Present 5e , 5e inset
TS28: dentate gyrus Present 5e
TS28: hippocampus CA1 Present 5e
TS28: hypothalamus Weak 5e
TS28: hippocampus CA2 Absent 5e
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory