Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Siglecftm1.2Avrk
Name:	sialic acid binding Ig-like lectin F; targeted mutation 1.2, Ajit Varki
MGI ID:	MGI:5543479
Gene:	Siglecf  Location: Chr7:43000765-43008955 bp, + strand  Genetic Position: Chr7, 28.25 cM, cytoband B3
Alliance:	Siglecftm1.2Avrk page

Germline Transmission:	Earliest citation of germline transmission: J:204811
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed the floxed exons 1 through 3. This allele lacks the neomycin resistance cassette. Flow cytometry confirmed the absence of protein expression on peripheral blood leukocytes. (J:204811)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Siglecf Mutation:	58 strains or lines available

Original:	J:204811 Zhang M, et al., Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 2007 May 15;109(10):4280-7
All:	3 reference(s)