Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sgo1Gt(neo-btk)1Dai
Name:	shugoshin 1; gene trap 1, Wei Dai
MGI ID:	MGI:5543407
Synonyms:	SGO1-
Gene:	Sgo1  Location: Chr17:53981814-53996361 bp, - strand  Genetic Position: Chr17, 27.92 cM
Alliance:	Sgo1Gt(neo-btk)1Dai page

Germline Transmission:	Earliest citation of germline transmission: J:204810
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: This gene trap vector includes a 5' viral long-terminal repeat, splice acceptor, neomycin resistance cassette, poly adenylation sequence, PGK promoter, Bruton tyrosine kinase coding sequence, splice donor and 3' viral long-terminal repeat. The vector inserted between exons 1 and 2 of the endogenous gene. Western blot analysis indicates an approximately 50% reduction of protein in heterozygotes. (J:204809)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgo1 Mutation:	29 strains or lines available

Original:	J:204810 Wang X, et al., sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell. 2008 Mar;14(3):331-41
All:	6 reference(s)