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Gene Expression Data
Assay Details
Assay
Reference: J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
Assay type: RNA in situ
MGI Accession ID: MGI:5541791
Gene symbol: Irx1
Gene name: Iroquois homeobox 1
Probe: RIKEN clone 5730541C20 subclone
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen GUDMAP:12550: embryonic day 15.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS23: urinary system Present GUDMAP:12550
TS23: metanephros Present GUDMAP:12550
TS23: renal cortex Present GUDMAP:12550
TS23: s-shaped body Present Regionally restricted GUDMAP:12550 Restricted expression in a small region of the S-shaped body.
TS23: distal segment of s-shaped body Absent GUDMAP:12550
TS23: renal connecting tubule of s-shaped body Absent GUDMAP:12550
TS23: proximal segment of s-shaped body Absent GUDMAP:12550
TS23: comma-shaped body Absent GUDMAP:12550
TS23: renal vesicle Absent GUDMAP:12550
TS23: nephrogenic interstitium Absent GUDMAP:12550
TS23: cap mesenchyme Absent GUDMAP:12550
TS23: pretubular aggregate Absent GUDMAP:12550
TS23: ureteric tip Absent GUDMAP:12550
TS23: ureteric tree terminal branch excluding tip itself Absent GUDMAP:12550
TS23: maturing renal corpuscle Absent GUDMAP:12550
TS23: capillary loop renal corpuscle Absent GUDMAP:12550
TS23: medial segment of s-shaped body Present Regionally restricted GUDMAP:12550
TS23: cortical renal tubule Present Regionally restricted GUDMAP:12550 The very restricted pattern in the tubules in both stage III-IV nephrons, immediately adjacent to the RC, would suggest that at least a portion of the distal tubule (macula densa region) is derived from the anlage of loop of Henle rather than the more distal tubular region of the earlier SSB/capillary loop stage nephrons. Due to the location adjacent to the vascular pole of the renal corpuscles suggests that these tubules may include the developing macula densa region.
TS23: cortical early proximal tubule Ambiguous GUDMAP:12550
TS23: early tubule Present GUDMAP:12550
TS23: developing capillary loop stage nephron group Present GUDMAP:12550
TS23: late tubule Present GUDMAP:12550
TS23: nephrogenic zone Absent GUDMAP:12550
TS23: cortical early distal tubule Present Regionally restricted GUDMAP:12550 Expression absent from early distal tubules of stage III capillary loop nephrons. Expression detected in early distal tubules of stage IV maturing nephrons. Expression is strongest in stage IV early distal tubules adjacent to the maturing renal corpuscle - possibly early macula densa.
TS23: renal connecting tubule Absent GUDMAP:12550
TS23: cortical collecting duct Absent GUDMAP:12550
TS23: renal cortical interstitium Absent GUDMAP:12550
TS23: anlage of loop of Henle of cortical renal tubule Present Regionally restricted GUDMAP:12550
TS23: pelvic urothelial lining Absent GUDMAP:12550
TS23: pelvic smooth muscle Absent GUDMAP:12550
TS23: perihilar interstitium Absent GUDMAP:12550
TS23: renal pelvis Absent GUDMAP:12550
TS23: medullary collecting duct Absent GUDMAP:12550
TS23: renal medullary interstitium Absent GUDMAP:12550
TS23: renal medullary vasculature Absent GUDMAP:12550
TS23: maturing nephron Present GUDMAP:12550
TS23: immature loop of Henle Present GUDMAP:12550
TS23: renal medulla Present GUDMAP:12550
TS23: renal cortical vasculature Absent GUDMAP:12550
TS23: collecting duct Absent GUDMAP:12550
TS23: ureteric trunk Absent GUDMAP:12550
TS23: renal interstitium Absent GUDMAP:12550
TS23: ureter Absent GUDMAP:12550
TS23: cortical renal tubule of capillary loop nephron group Present GUDMAP:12550
TS23: cortical renal tubule of maturing nephron group Present GUDMAP:12550
TS23: early distal tubule of maturing nephron Present GUDMAP:12550 Expression is strongest in stage IV early distal tubules adjacent to the maturing renal corpuscle - most likely the early developing macula densa region of the future distal convoluted tubule.
TS23: early proximal tubule of capillary loop nephron Ambiguous GUDMAP:12550
TS23: renal connecting tubule of capillary loop nephron Absent GUDMAP:12550
TS23: early proximal tubule of maturing nephron Absent GUDMAP:12550
TS23: renal connecting tubule of maturing nephron Absent GUDMAP:12550
TS23: early distal tubule of capillary loop nephron Absent GUDMAP:12550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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