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Gene Expression Data
Assay Details
Assay
Reference: J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
Assay type: RNA in situ
MGI Accession ID: MGI:5540747
Gene symbol: Dkk1
Gene name: dickkopf WNT signaling pathway inhibitor 1
Probe: RIKEN clone D030025M19 subclone
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen GUDMAP:9041: embryonic day 13.5 (more )
Note: Labeling was visualized using NBT/BCIP. Male and female were examined; only the male is shown. Annotators reported the male expression pattern in the metanephros is identical to female.
Structure Level Pattern Image Note
TS21: urinary system Present Regionally restricted GUDMAP:9041
TS21: metanephros Present Regionally restricted GUDMAP:9041
TS21: early nephron Present GUDMAP:9041
TS21: cap mesenchyme Absent GUDMAP:9041
TS21: renal capsule Absent GUDMAP:9041
TS21: ureteric tip Absent GUDMAP:9041
TS21: nephrogenic interstitium Ambiguous GUDMAP:9041 possible expression in a subset of the nephrogenic interstitium
TS21: ureter Ambiguous GUDMAP:9041 possible expression
Specimen GUDMAP:9042: embryonic day 10.5 (more )
Note: Labeling was visualized using NBT/BCIP.
Structure Level Pattern Image Note
TS17: genitourinary system Present Regionally restricted GUDMAP:9042
TS17: mesonephros Present Regionally restricted GUDMAP:9042
TS17: mesonephric tubule Present Regionally restricted GUDMAP:9042 graded expression
TS17: cranial mesonephric tubule Present GUDMAP:9042
TS17: rest of cranial mesonephric tubule Present GUDMAP:9042
TS17: caudal mesonephric tubule Present GUDMAP:9042
TS17: nephric duct, mesonephric portion Present GUDMAP:9042
TS17: nephric duct, metanephric portion Present GUDMAP:9042
TS17: nephric duct Present GUDMAP:9042
TS17: genitourinary system mesenchyme Absent GUDMAP:9042
TS17: gonad primordium Absent GUDMAP:9042
TS17: mesonephros mesenchyme Absent GUDMAP:9042
TS17: metanephric mesenchyme Absent GUDMAP:9042
TS17: developing vasculature of genitourinary system Absent GUDMAP:9042
Specimen GUDMAP:9045: embryonic day 15.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS23: urinary system Present Regionally restricted GUDMAP:9045
TS23: metanephros Present Regionally restricted GUDMAP:9045
TS23: renal cortex Present Regionally restricted GUDMAP:9045
TS23: renal vesicle Present Regionally restricted GUDMAP:9045 distal expression; expression only detected in subset of the distal renal vesicle
TS23: comma-shaped body Present Regionally restricted GUDMAP:9045 distal expression; expression in a subset of the upper limb of comma-shaped body
TS23: upper limb of comma-shaped body Present Regionally restricted GUDMAP:9045 expression in subset of the upper limb of comma-shaped body
TS23: s-shaped body Present Regionally restricted GUDMAP:9045 medial expression; expression in a subset of the medial segment
TS23: medial segment of s-shaped body Present Regionally restricted GUDMAP:9045 expression in a subset of the medial segment of s-shaped body
TS23: cortical renal tubule Present Regionally restricted GUDMAP:9045 only very weak expression detected in the early proximal tubules of capillary loop stage nephrons only
TS23: cortical early proximal tubule Present Regionally restricted GUDMAP:9045 only very weak expression detected in the early proximal tubules of capillary loop stage nephrons only
TS23: renal cortical interstitium Present Regionally restricted GUDMAP:9045 spotted expression; expression in small subsets of cells adjacent to the nephrogenic zone; may extend into the nephrogenic interstitium
TS23: renal capsule Absent GUDMAP:9045
TS23: cap mesenchyme Absent GUDMAP:9045
TS23: ureteric tip Absent GUDMAP:9045
TS23: ureteric tree terminal branch excluding tip itself Absent GUDMAP:9045
TS23: lower limb of comma-shaped body Absent GUDMAP:9045
TS23: renal connecting tubule of s-shaped body Absent GUDMAP:9045
TS23: distal segment of s-shaped body Absent GUDMAP:9045
TS23: proximal segment of s-shaped body Absent GUDMAP:9045
TS23: visceral epithelium of s-shaped body Absent GUDMAP:9045
TS23: parietal epithelium of s-shaped body Absent GUDMAP:9045
TS23: cortical collecting duct Absent GUDMAP:9045
TS23: renal cortical vasculature Absent GUDMAP:9045
TS23: renal cortical arterial system Absent GUDMAP:9045
TS23: renal cortical venous system Absent GUDMAP:9045
TS23: renal cortical capillary Absent GUDMAP:9045
TS23: renal medulla Absent GUDMAP:9045
TS23: immature loop of Henle Absent GUDMAP:9045
TS23: straight limb of immature loop of Henle Absent GUDMAP:9045
TS23: bend of immature loop of Henle Absent GUDMAP:9045
TS23: renal medullary interstitium Absent GUDMAP:9045
TS23: renal medullary vasculature Absent GUDMAP:9045
TS23: renal medullary arterial system Absent GUDMAP:9045
TS23: renal medullary venous system Absent GUDMAP:9045
TS23: renal medullary capillary Absent GUDMAP:9045
TS23: medullary collecting duct Absent GUDMAP:9045
TS23: renal calyx Absent GUDMAP:9045
TS23: renal pelvis Absent GUDMAP:9045
TS23: pelvic urothelial lining Absent GUDMAP:9045
TS23: pelvic smooth muscle Absent GUDMAP:9045
TS23: perihilar interstitium Absent GUDMAP:9045
TS23: capillary loop renal corpuscle Absent GUDMAP:9045
TS23: visceral epithelium of capillary loop renal corpuscle Absent GUDMAP:9045
TS23: parietal epithelium of capillary loop renal corpuscle Absent GUDMAP:9045
TS23: presumptive mesangium of capillary loop renal corpuscle Absent GUDMAP:9045
TS23: presumptive endothelium of capillary loop renal corpuscle Absent GUDMAP:9045
TS23: associated interstitium of capillary loop renal corpuscle Absent GUDMAP:9045
TS23: maturing renal corpuscle Absent GUDMAP:9045
TS23: maturing glomerular tuft Absent GUDMAP:9045
TS23: glomerular capillary system of maturing glomerular tuft Absent GUDMAP:9045
TS23: glomerular basement membrane of maturing renal corpuscle Absent GUDMAP:9045
TS23: glomerular mesangium of maturing glomerular tuft Absent GUDMAP:9045
TS23: visceral epithelium of maturing renal corpuscle Absent GUDMAP:9045
TS23: Bowman's capsule of maturing renal corpuscle Absent GUDMAP:9045
TS23: parietal epithelium of maturing renal corpuscle Absent GUDMAP:9045
TS23: glomerular mesangium of maturing renal corpuscle Absent GUDMAP:9045
TS23: juxtaglomerular arteriole Absent GUDMAP:9045
TS23: anlage of loop of Henle of cortical renal tubule Absent GUDMAP:9045
TS23: cortical early distal tubule Absent GUDMAP:9045
TS23: renal connecting tubule Absent GUDMAP:9045
TS23: nephrogenic zone Ambiguous GUDMAP:9045 possible expression in a subset of cells
TS23: pretubular aggregate Ambiguous GUDMAP:9045
TS23: nephrogenic interstitium Ambiguous GUDMAP:9045 possible expression in a subset of cells; expression in small subsets of cortical interstitium cells adjacent to the nephrogenic zone; may extend into the nephrogenic interstitium
TS23: distal renal vesicle Present Regionally restricted GUDMAP:9045 expression in a subset of
TS23: cortical renal tubule of capillary loop nephron group Present Regionally restricted GUDMAP:9045 only very weak expression detected in the early proximal tubules of capillary loop stage nephrons only
TS23: early proximal tubule of capillary loop nephron Present GUDMAP:9045
TS23: proximal renal vesicle Absent GUDMAP:9045
TS23: renal connecting segment of renal vesicle Absent GUDMAP:9045
TS23: renal connecting segment of comma-shaped body Absent GUDMAP:9045
TS23: cortical renal tubule of maturing nephron group Absent GUDMAP:9045
TS23: early proximal tubule of maturing nephron Absent GUDMAP:9045
TS23: early distal tubule of maturing nephron Absent GUDMAP:9045
TS23: early distal tubule of capillary loop nephron Absent GUDMAP:9045
TS23: renal connecting tubule of capillary loop nephron Absent GUDMAP:9045
Specimen GUDMAP:9046: embryonic day 15.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS23: ureter Absent GUDMAP:9046
TS23: urothelium of ureter Absent GUDMAP:9046
TS23: superficial cell layer of ureter Absent GUDMAP:9046
TS23: intermediate cell layer of ureter Absent GUDMAP:9046
TS23: basal cell layer of ureter Absent GUDMAP:9046
TS23: ureteral mesenchyme Absent GUDMAP:9046
TS23: ureteral mesenchyme subepithelial layer Absent GUDMAP:9046
TS23: ureteral smooth muscle layer Absent GUDMAP:9046
TS23: ureteral smooth muscle layer smooth muscle component Absent GUDMAP:9046
TS23: ureteral smooth muscle layer interstitium Absent GUDMAP:9046
TS23: ureteral mesenchyme outer layer Absent GUDMAP:9046
TS23: ureteral vasculature Absent GUDMAP:9046
Specimen GUDMAP:9738: embryonic day 10.5 (more )
Note: Labeling was visualized using NBT/BCIP.
Structure Level Pattern Image Note
TS17: genitourinary system Present Regionally restricted GUDMAP:9738
TS17: mesonephros Present Regionally restricted GUDMAP:9738
TS17: mesonephric tubule Present Graded GUDMAP:9738 strong expression in cranial tubules and weak in caudal tubules
TS17: cranial mesonephric tubule Present GUDMAP:9738
TS17: caudal mesonephric tubule Present GUDMAP:9738 weak expression compared to cranial tubules
TS17: nephric duct, mesonephric portion Present GUDMAP:9738
TS17: nephric duct, metanephric portion Present GUDMAP:9738
TS17: genitourinary system mesenchyme Absent GUDMAP:9738
TS17: gonad primordium Absent GUDMAP:9738
TS17: mesonephros mesenchyme Absent GUDMAP:9738
TS17: metanephric mesenchyme Absent GUDMAP:9738
Specimen GUDMAP:9739: embryonic day 13.5 (more )
Note: Labeling was visualized using NBT/BCIP.
Structure Level Pattern Image Note
TS21: male reproductive system Present Regionally restricted GUDMAP:9739
TS21: mesonephros of male Present Regionally restricted GUDMAP:9739
TS21: paramesonephric duct of male, mesonephric portion Present GUDMAP:9739
TS21: mesonephric tubule of male Present Regionally restricted GUDMAP:9739 tubules present only in small region
TS21: testis Present Regionally restricted GUDMAP:9739
TS21: coelomic epithelium of testis Present GUDMAP:9739
TS21: mesonephric mesenchyme of male Absent GUDMAP:9739
TS21: primary sex cord Absent GUDMAP:9739
TS21: interstitium of the testis Absent GUDMAP:9739
TS21: nephric duct of male, mesonephric portion Absent GUDMAP:9739
Specimen GUDMAP:9740: embryonic day 13.5 (more )
Note: Labeling was visualized using NBT/BCIP. Male and female were examined; only the male is shown. Annotators reported the male expression pattern in the metanephros is identical to female.
Structure Level Pattern Image Note
TS21: urinary system Present Regionally restricted GUDMAP:9740
TS21: metanephros Present Regionally restricted GUDMAP:9740 expression in early tubules (early nephrons) as well as another unidentifiable structure
TS21: urogenital mesentery Absent GUDMAP:9740
Specimen GUDMAP:9741: embryonic day 13.5 (more )
Note: Labeling was visualized using NBT/BCIP.
Structure Level Pattern Image Note
TS21: female reproductive system Present Regionally restricted GUDMAP:9741
TS21: mesonephros of female Present Regionally restricted GUDMAP:9741
TS21: mesonephric tubule of female Present Regionally restricted GUDMAP:9741
TS21: mesonephric mesenchyme of female Absent GUDMAP:9741
TS21: nephric duct of female, mesonephric portion Absent GUDMAP:9741
TS21: paramesonephric duct of female, mesonephric portion Absent GUDMAP:9741
TS21: ovary Absent GUDMAP:9741
Specimen GUDMAP:11733: embryonic day 13.5 (more )
Note: Labeling was visualized using BM purple. This specimen annotates metanephros. Expression pattern for male was identical but images not shown.
Structure Level Pattern Image Note
TS21: metanephros Present Spotted GUDMAP:11733
TS21: urinary system mesentery Ambiguous GUDMAP:11733
TS21: ureter Ambiguous GUDMAP:11733
TS21: primitive bladder Ambiguous GUDMAP:11733
TS21: renal interstitium Present GUDMAP:11733
TS21: cap mesenchyme Absent GUDMAP:11733
TS21: renal capsule Absent GUDMAP:11733
Specimen GUDMAP:11734: embryonic day 13.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS21: paramesonephric duct of male, mesonephric portion Present GUDMAP:11734
TS21: nephric duct of male, mesonephric portion Absent GUDMAP:11734
TS21: mesonephric mesenchyme of male Absent GUDMAP:11734
TS21: mesonephric tubule of male Absent GUDMAP:11734
TS21: paramesonephric duct of male, rest of Present GUDMAP:11734
TS21: nephric duct of male, rest of Absent GUDMAP:11734
TS21: testis Present Spotted GUDMAP:11734
TS21: genital tubercle of male Present GUDMAP:11734
TS21: preputial swelling of male Absent GUDMAP:11734
TS21: mesonephros of male Present GUDMAP:11734
TS21: interstitial vessel Ambiguous GUDMAP:11734
TS21: coelomic vessel Ambiguous GUDMAP:11734
TS21: developing vasculature of testis Ambiguous GUDMAP:11734
TS21: distal genital tubercle of male Present Regionally restricted GUDMAP:11734 proximal expression
TS21: mesenchyme of distal genital tubercle of male Present GUDMAP:11734
TS21: epithelium of phallic urethra of male Absent GUDMAP:11734
Specimen GUDMAP:11735: embryonic day 13.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS21: mesonephros of female Ambiguous GUDMAP:11735
TS21: paramesonephric duct of female, rest of Ambiguous GUDMAP:11735
TS21: nephric duct of female, rest of Ambiguous GUDMAP:11735
TS21: ovary Ambiguous GUDMAP:11735
TS21: genital tubercle of female Present GUDMAP:11735
TS21: preputial swelling of female Absent GUDMAP:11735
TS21: female reproductive system Present Spotted GUDMAP:11735
TS21: distal genital tubercle of female Present Regionally restricted GUDMAP:11735 proximal expression
TS21: mesenchyme of distal genital tubercle of female Present GUDMAP:11735
TS21: epithelium of phallic urethra of female Absent GUDMAP:11735
Specimen GUDMAP:11736: embryonic day 10.5 (more )
Note: Labeling was visualized using BM purple.
Structure Level Pattern Image Note
TS17: genital swelling Ambiguous GUDMAP:11736
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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