Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx3tm3.2Moon
Name:	T-box 3; targeted mutation 3.2, Anne M Moon
MGI ID:	MGI:5538565
Synonyms:	Tbx3deltaflox
Gene:	Tbx3  Location: Chr5:119808734-119822789 bp, + strand  Genetic Position: Chr5, 60.34 cM
Alliance:	Tbx3tm3.2Moon page

Germline Transmission:	Earliest citation of germline transmission: J:179977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxA1 site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxA1 site was inserted in intron 1. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 1. Immunohistochemistry confirmed the absence of protein expression in the sinoatrial node. (J:179977)

Generation of the Tbx3tm1.1Moon, Tbx3tm2Moon, Tbx3tm2.1Moon, Tbx3tm3.1Moon, and Tbx3tm3.2Moon alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	243 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:	49 strains or lines available

Original:	J:179977 Frank DU, et al., Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E154-63
All:	5 reference(s)