Sidt2tm1.1Hzha
Targeted Allele Detail
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Symbol: |
Sidt2tm1.1Hzha |
Name: |
SID1 transmembrane family, member 2; targeted mutation 1.1, Huiwen Zhang |
MGI ID: |
MGI:5532825 |
Gene: |
Sidt2 Location: Chr9:45849155-45866556 bp, - strand Genetic Position: Chr9, 25.36 cM
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Alliance: |
Sidt2tm1.1Hzha page
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Increase in body size of Sidt2tm1.1Hzha/Sidt2tm1.1Hzha adult mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:204228
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Parent Cell Line: |
PRX-129S6 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2, but left the FRT-flanked neomycin resistance cassette intact. Western blot analysis confirmed decreased protein expression in the liver.
(J:204228)
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Generation of the Sidt2tm1.1Hzha allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sidt2 Mutation: |
46 strains or lines available
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Original: |
J:204228 Gao J, et al., Impaired glucose tolerance in a mouse model of sidt2 deficiency. PLoS One. 2013;8(6):e66139 |
All: |
4 reference(s) |
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