Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Axin2tm1.1(cre/ERT2/tdTomato)Eem
Name:	axin 2; targeted mutation 1.1, Edward E Morrisey
MGI ID:	MGI:5532194
Synonyms:	Axin2-CreERT2/tdT, Axin2tm1.1(cre/ERT2/tdTomato)Smr
Gene:	Axin2  Location: Chr11:108811175-108841609 bp, + strand  Genetic Position: Chr11, 71.83 cM
Alliance:	Axin2tm1.1(cre/ERT2/tdTomato)Eem page

Germline Transmission:	Earliest citation of germline transmission: J:204142
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Axin2tm1.1(cre/ERT2/tdTomato)Eem expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Axin2 (MGI:1270862)   Mutation details: cDNA encoding cre/ERT2 fused with tandem dimer Tomato cDNA (tdTomato) and a human growth hormone intron and polyadenylation site was inserted into the Axin2 locus downstream of the translation initiation codon using homologous recombination in ES cells. The neo selection cassette was excised by crossing germline animals to Flp1-expressing mice. (J:204142)

Activity:	Tissue activity of this recombinase allele
Driver:	Axin2 (mouse) Summary of all recombinase alleles driven by Axin2. Alliance mouse Axin2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Axin2 Mutation:	43 strains or lines available

Original:	J:204142 Choi YS, et al., Distinct Functions for Wnt/beta-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell. 2013 Dec 5;13(6):720-33
All:	8 reference(s)