Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(ACTB-THRB*)#Syc
Name:	transgene insertion, Sheue-yann Cheng
MGI ID:	MGI:5529516
Transgene:	Tg(ACTB-THRB*)#Syc  Location: unknown
Alliance:	Tg(ACTB-THRB*)#Syc page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(ACTB-THRB*)#Syc expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human THRB (7068) Thrb  (MGI:98743)   Mutation details: This transgene consists of the human beta-actin promoter driving the expression of a human thyroid hormone beta1 receptor cDNA isolated from the PV kindred with Generalized Resistance to Thyroid Hormone containing a C-insertion at nucleotide 1627 (codon 443). This insertion results in a frame shift of the carboxy terminal 16 amino acids resulting in a total loss of T3-binding and transcriptional activation behaving as a dominant negative. Three founder lines were established: A,D, and G. RT-PCR and immunohistochemistry confirmed expression of RNA and protein. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:134187)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:134187 Wong R, et al., Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity. Mol Med. 1997 May;3(5):303-14
All:	2 reference(s)