Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ascl3tm1.1(EGFP/cre)Ovi
Name:	achaete-scute family bHLH transcription factor 3; targeted mutation 1.1, Catherine E Ovitt
MGI ID:	MGI:5520171
Gene:	Ascl3  Location: Chr7:109326672-109330933 bp, - strand  Genetic Position: Chr7, 57.46 cM
Alliance:	Ascl3tm1.1(EGFP/cre)Ovi page

Mouse Generated:	Earliest citation of chimera generation: J:139151
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Recombinase, Reporter) Mutations:    Insertion, Intragenic deletion   Ascl3tm1.1(EGFP/cre)Ovi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ascl3 (MGI:1928820)   Mutation details: A targeting vector was constructed to insert an EGFP-Cre recombinase fusion expression cassette with a 3' beta-globin polyadenylation site and loxP-flanked PGK-neomycin cassette into exon 2, replacing the entire coding sequence. Cre-mediated recombination removed the neomycin cassette. (J:101977, J:139151)

Activity:	Tissue activity of this recombinase allele
Driver:	Ascl3 (mouse) Summary of all recombinase alleles driven by Ascl3. Alliance mouse Ascl3 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ascl3 Mutation:	9 strains or lines available

Original:	J:139151 Bullard T, et al., Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol. 2008 Aug 1;320(1):72-8
All:	3 reference(s)