Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Igs1tm10(CAG-Bgeo,-Fzd6)Nat
Name:	intergenic site 1; targeted mutation 10, Jeremy Nathans
MGI ID:	MGI:5510967
Synonyms:	Iis1tm10(CAG-Bgeo,-Fz6)Nat, Ubbtm2(CAG-Fzd6)Nat, Z/3HAFz6
Gene:	Igs1  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance:	Igs1tm10(CAG-Bgeo,-Fzd6)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:217610
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change) Mutation:    Insertion   Igs1tm10(CAG-Bgeo,-Fzd6)Nat expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Fzd6 (MGI:108474)   Mutation details: The following elements were inserted, in order into a region 2 kb 5' of the Ubb gene by targeted recombination: CMV enhancer/beta-actin promoter, loxP site, beta-geo, 3 stop transcription sites, loxP site, 3HA-Fzd6, rabbit beta-globin 3' UTR. The 3HA tag is inserted after the signal peptide and before the cysteine-rich domain of Fzd6. (J:217610)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igs1 Mutation:	10 strains or lines available

Original:	J:217610 Hua ZL, et al., Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development. 2014 Oct;141(20):3944-54
All:	1 reference(s)