Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm6(Fzd6)Nat
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Jeremy Nathans
MGI ID:	MGI:5510965
Synonyms:	R26-LSL-3HAFz6, ROSA26-3xHA-Fz6
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm6(Fzd6)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:217610
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change) Mutation:    Insertion   Gt(ROSA)26Sortm6(Fzd6)Nat expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Fzd6 (MGI:108474)   Mutation details: The following elements were inserted, in the following order, into the locus by homologous recombination: loxP-three stop transcription signals-loxP, a Fzd6 coding region with a triple hemagglutinin (HA) tag inserted immediately C-terminal to the signal peptide. (J:217610)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:217610 Hua ZL, et al., Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development. 2014 Oct;141(20):3944-54
All:	4 reference(s)