Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Tagln-Pth1r*)2Towl
Name:	transgene insertion 2, Dwight Towler
MGI ID:	MGI:5509011
Transgene:	Tg(Tagln-Pth1r*)2Towl  Location: unknown
Alliance:	Tg(Tagln-Pth1r*)2Towl page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence) Mutation:    Insertion   Tg(Tagln-Pth1r*)2Towl expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Pth1r (MGI:97801)   Mutation details: The vascular smooth muscle cell-specific mouse Tagln (SM22) promoter was used to drive expression of a 1.8 kb cDNA encoding the open reading frame of the H223R constitutively active form of mouse Pthr1 upstream of rabbit beta-globin 3'UTR and polyA sequences. (J:175050)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:175050 Cheng SL, et al., Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res. 2010 Jul 23;107(2):271-82
All:	1 reference(s)