Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Clec9atm2.1(icre)Crs
Name:	C-type lectin domain family 9, member a; targeted mutation 2.1, Caetano Reis e Sousa
MGI ID:	MGI:5502446
Synonyms:	Clec9acre
Gene:	Clec9a  Location: Chr6:129385825-129401726 bp, + strand  Genetic Position: Chr6, 63.3 cM
Alliance:	Clec9atm2.1(icre)Crs page

Germline Transmission:	Earliest citation of germline transmission: J:199355
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Clec9atm2.1(icre)Crs expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Clec9a (MGI:2444608)   Mutation details: An existing targeting vector was modified by inserting a codon-improved cre sequence in place of the EGFP sequence in the pFloxRI-C9a-EGFP construct. This construct was electroporated into PRX-B6N (Primogenix) for homologous recombination. Animals carrying the cre allele were crossed to PGK-cre mice to delete the floxed neomycin selection cassette. (J:199355)

Activity:	Tissue activity of this recombinase allele
Driver:	Clec9a (mouse) Summary of all recombinase alleles driven by Clec9a. Comparative matrix view of recombinase activities Alliance mouse Clec9a gene page

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clec9a Mutation:	28 strains or lines available

Original:	J:199355 Schraml BU, et al., Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage. Cell. 2013 Aug 15;154(4):843-58
All:	16 reference(s)