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Gene Expression Data
Assay Details
Assay
Reference: J:83364 Ruest LB, et al., Dhand-cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev Biol. 2003 May 15;257(2):263-77
Assay type: RNA in situ
MGI Accession ID: MGI:5502367
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: dhand probe16
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 3C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tongue Present Regionally restricted 3C Expression was detected in the lamina propria.
TS21: submandibular gland primordium mesenchyme Present Regionally restricted 3C Expression was detected in the mesenchyme surrounding the proximal ducts of the submandibular gland.
TS21: Meckel's cartilage Ambiguous 3C Expression was described as being very little or virtually undetectable.
TS21: mandible Ambiguous 3C Expression was described as being very little or virtually undetectable.

Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: scapula pre-cartilage condensation Absent

Specimen 3F: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: mandible Weak Scattered 3F
TS26: Meckel's cartilage Ambiguous 3F Very little expression was seen in Meckel's cartilage.

Specimen 3I: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: Meckel's cartilage Absent 3I
TS26: mandible Absent 3I
TS26: sympathetic ganglion Present 3I

Specimen 4C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: middle ear Ambiguous 4C Very little expression is observed in the middle ear.
TS21: sympathetic ganglion Present 4C
TS21: trigeminal ganglion Present Regionally restricted 4C Expression was detected in the mandibular branch of the trigeminal ganglion.

Specimen 4F: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: temporal bone Ambiguous Regionally restricted 4F Little expression is observed in the tympanic bone.
TS26: mandible Ambiguous Regionally restricted 4F Little expression is observed in the gonial bone.
TS26: Meckel's cartilage Ambiguous Regionally restricted 4F Little expression is observed in Meckel's cartilage.
TS26: head Weak Regionally restricted 4F Faint expression was found along some of the head vasculature.

Specimen 4I: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: incus Absent 4I
TS26: malleus Absent 4I

Specimen 4L: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: incus Absent 4L
TS26: stapes Absent 4L
TS26: malleus Absent 4L Expression was not detected in the manubrium of the malleus.

Specimen 4O: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: sympathetic ganglion Present 4O
TS26: glossopharyngeal ganglion Weak 4O

Specimen 4R: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: hyoid Absent 4R
TS26: adipose tissue Strong Regionally restricted 4R Strong expression was detected in the adipose tissue at the base of the neck.

Specimen 4R': embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 4R'

Specimen 5C: embryonic day 13.5 (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: tongue Present 5C
TS21: lower jaw incisor mesenchyme Present Regionally restricted 5C Expression was detected in the mesenchyme surrounding the incisor enamel organs.
TS21: Meckel's cartilage Absent 5C

Specimen 5F: embryonic day 13.5 (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: mandible mesenchyme Absent 5F Expression was not observed around the mandibular molars.

Specimen 5I: embryonic day 15.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS23: incisor dental papilla Present 5I
TS23: incisor mesenchyme Present 5I Expression was detected in the mesenchyme surrounding the dental papilla.
TS23: Meckel's cartilage Absent 5I

Specimen 5L: embryonic day 15.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS23: lower jaw molar dental papilla Absent 5L
TS23: tongue Strong Regionally restricted 5L Strong expression was detected in the lamina propria of the tongue.

Specimen 5O: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lower jaw incisor dental papilla Weak 5O
TS26: mandible Weak Regionally restricted 5O Weak expression was observed in distal mandibular bone.
TS26: lower jaw mesenchyme Weak Regionally restricted 5O Weak expression was detected in the mesenchyme surrounding the incisor.
TS26: Meckel's cartilage Absent 5O

Specimen 5R: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lower jaw molar Absent 5R No signal was detected in the mandibular molar or surrounding mesenchyme.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory