About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:28764 Gasca S, et al., Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995;17(2):141-54
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5501021
Gene symbol: Cobl
Gene name: cordon-bleu WH2 repeat
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 7.5; CoblC101/Cobl+ (more )
Note: Late primitive streak stage.
Structure Level Pattern Image Note
TS11: node Present Regionally restricted 1A Expressed in a small group of cells at the distal tip of the embryo in the presumptive node region.

Specimen 1B: embryonic day 7.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS11: node Present Regionally restricted 1B Expressed in a small group of cells at the distal tip of the embryo in the presumptive node region.

Specimen 1C: embryonic day 7.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS11: node Present 1C
TS11: notochordal process Present 1C Expressed along the axis posterior to the node in the head-process and into the hindgut.
TS11: embryo Present Regionally restricted 1C Expressed in the node and extended anteriorly in the midline, also in some cells just posterior to the node and in more lateral regions.

Specimen 1D E7.5: embryonic day 7.5; CoblC101/Cobl+ (more )
Note: Neural plate, presomite stage.
Structure Level Pattern Image Note
TS11: node Present 1D E7.5

Specimen 1D E8.0: embryonic day 8.0; CoblC101/Cobl+ (more )
Note: Late headfold stage, 3 somites.
Structure Level Pattern Image Note
TS12: foregut diverticulum Present 1D E8.0
TS12: node Present 1D E8.0
TS12: notochordal plate Present 1D E8.0

Specimen 1D E8.5: embryonic day 8.5; CoblC101/Cobl+ (more )
Note: Before turning, 8 somites.
Structure Level Pattern Image Note
TS13: foregut diverticulum Present Regionally restricted 1D E8.5 (8s) Expressed in the dorsal roof.
TS13: hindgut diverticulum Present Regionally restricted 1D E8.5 (8s) Expressed in the dorsal roof.
TS13: notochord Present Widespread 1D E8.5 (8s) Expressed along the entire axis from its anterior limit below the midbrain to the base of the allantois.
TS13: primitive streak Present Regionally restricted 1D E8.5 (8s) Expressed in the most anterior region.

Specimen 1D E8.5 older: embryonic day 8.5; CoblC101/Cobl+ (more )
Note: Beginning of turning stage, 10 somites.
Structure Level Pattern Image Note
TS13: foregut diverticulum Present Regionally restricted 1D E8.5 (10s) Expressed in the dorsal roof.
TS13: hindgut diverticulum Present Regionally restricted 1D E8.5 (10s) Expressed in the dorsal roof.
TS13: notochord Present Widespread 1D E8.5 (10s) Expressed along the entire axis from the head to the tail bud.
TS13: primitive streak Present Regionally restricted 1D E8.5 (10s) Expressed in the most anterior region.

Specimen 1D E9.5: embryonic day 9.5; CoblC101/Cobl+ (more )
Note: End of turning stage, 13 somites.
Structure Level Pattern Image Note
TS15: branchial arch endoderm Present 1D E9.5
TS15: hepatic primordium Present 1D E9.5
TS15: neural tube floor plate Present 1D E9.5
TS15: notochord Present 1D E9.5
TS15: gut Present Regionally restricted 1D E9.5 Expressed in the roof.

Specimen 1E: embryonic day 9.5; CoblC101/Cobl+ (more )
Note: 25 somites.
Structure Level Pattern Image Note
TS15: branchial arch endoderm Present 1E
TS15: future midbrain floor plate Present 1E
TS15: hepatic primordium Present 1E
TS15: neural tube floor plate Present 1E
TS15: somite Present 1E
TS15: olfactory placode Present Regionally restricted 1E Expressed in the mesenchyme cells.
TS15: notochord Present Regionally restricted 1E Expressed in the anterior end.

Specimen 1F: embryonic day 10.5; CoblC101/Cobl+ (more )
Note: 30 somites.
Structure Level Pattern Image Note
TS17: somite Present Regionally restricted 1F Expressed in a medial subset of cells.

Specimen 2A: embryonic day 7.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS11: node Present Regionally restricted 2A Expression is restricted to the mesoderm layer.

Specimen 2B: embryonic day 8.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS13: neural tube floor plate Present 2B
TS13: notochord Present 2B
TS13: foregut diverticulum Present Regionally restricted 2B Expressed in the roof.
TS13: hindgut diverticulum Present Regionally restricted 2B Expressed in the roof.

Specimen 2C: embryonic day 10.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS17: somite Present Regionally restricted 2C Expressed in a medial subset of cells.
TS17: gut Present 2C
TS17: neural tube floor plate Present 2C
TS17: notochord Present 2C
TS17: stomach mesentery Present 2C Expressed in the mesogastrium.
TS17: nephric duct Weak 2C Expressed in the Wolffian ducts.
TS17: trunk mesenchyme Present Regionally restricted 2C Expressed in the mesenchyme surrounding the floor plate and notochord.
TS17: mesonephric tubule Absent 2C

Specimen 2D: embryonic day 10.5; CoblC101/Cobl+ (more )
Note: 30 somites.
Structure Level Pattern Image Note
TS17: midbrain floor plate Present Regionally restricted 2D Expression is restricted in the posterior.
TS17: head mesenchyme Present Regionally restricted 2D Expressed in some cells.

Specimen not shown: embryonic day 8.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS13: future midbrain floor plate Present
TS13: future prosencephalon floor plate Absent

Specimen not shown: embryonic day 10.0; CoblC101/Cobl+ (more )
Note: 25 somites.
Structure Level Pattern Image Note
TS15: head mesenchyme Present Regionally restricted Expressed in the forebrain region.
TS15: sclerotome Present

Specimen not shown: embryonic day 10.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS17: lung Present
TS17: apical ectodermal ridge Weak
TS17: heart Absent

Specimen not shown: embryonic day 11.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS19: somite Strong

Specimen not shown: embryonic day 12.5; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS20: spinal cord floor plate Present
TS20: brain Present Regionally restricted Expressed in the roof plate and various parts of the brain.

Specimen not shown: postnatal newborn; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS27: brain Present
TS27: skin Present

Specimen not shown: postnatal adult; CoblC101/Cobl+ (more )
Structure Level Pattern Image Note
TS28: brain Present
TS28: skin Present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory