Aurkatm1.2Sbsn
Targeted Allele Detail
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Symbol: |
Aurkatm1.2Sbsn |
Name: |
aurora kinase A; targeted mutation 1.2, Subrata Sen |
MGI ID: |
MGI:5498678 |
Gene: |
Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
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Alliance: |
Aurkatm1.2Sbsn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:198479
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression.
(J:198479)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Aurka Mutation: |
40 strains or lines available
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Original: |
J:198479 Sasai K, et al., Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene. 2008 Jul 3;27(29):4122-7 |
All: |
1 reference(s) |
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