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Gene Expression Data
Assay Details
Assay
Reference: J:59920 St Amand TR, et al., Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol. 2000 Jan 15;217(2):323-32
Assay type: RNA in situ
MGI Accession ID: MGI:5494488
Gene symbol: Pitx2
Gene name: paired-like homeodomain transcription factor 2
Probe: Pitx2 probe16
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present Regionally restricted 1B Expressed at the sites of future odontogenesis.

Specimen 1D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandible primordium Strong Regionally restricted 1D Expressed in the dental placodes of both incisor and molar.
TS19: oral epithelium Present 1D Expression began to fade.

Specimen 1F: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandible primordium Present Regionally restricted 1F Expression is restricted to the dental epithelium of both molar and incisor.

Specimen 1I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Strong 1I Particularly at the tips where cells are dividing.

Specimen 1J: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Strong 1J Particularly at the tips where cells are dividing.

Specimen 1M: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw incisor epithelium Strong 1M Particularly at the tips where cells are dividing.

Specimen 1N: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw molar epithelium Strong 1N Particularly at the tips where cells are dividing.
TS22: enamel knot Weak 1N

Specimen 1Q: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Strong Regionally restricted 1Q
TS25: outer enamel epithelium Ambiguous 1Q No or weak expression was detected in the outer layer.

Specimen 1R: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Strong Regionally restricted 1R Expressed in the inner enamel epithelia, particularly at the tips where cells are dividing.
TS25: outer enamel epithelium Ambiguous 1R Expression was down-regulated.

Specimen 2D: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch mandibular component Weak 2D

Specimen 4C: embryonic day 17.5; Msx2tm1Rilm/Msx2tm1Rilm (more )
Structure Level Pattern Image Note
TS25: lower jaw incisor Ambiguous 4C Expression is dramatically down-regulated.

Specimen 4D: embryonic day 17.5; Msx2tm1Rilm/Msx2tm1Rilm (more )
Structure Level Pattern Image Note
TS25: lower jaw molar Present 4D No overt difference, compared with wild type expression.

Specimen not shown: embryonic day 13.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Present No overt difference, compared with wild type expression.
TS21: lower jaw molar epithelium Present No overt difference, compared with wild type expression.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory