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Gene Expression Data
Assay Details
Assay
Reference: J:59920 St Amand TR, et al., Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol. 2000 Jan 15;217(2):323-32
Assay type: RNA in situ
MGI Accession ID: MGI:5494446
Gene symbol: Pitx1
Gene name: paired-like homeodomain transcription factor 1
Probe: Pitx1 probe5
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present Widespread 1A Expressed in a widespread domain which covers the region of odontogenesis.
Specimen 1A inset: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component endoderm Present 1A inset
TS17: 1st branchial arch mandibular component mesenchyme Present 1A inset
Specimen 1C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandible primordium Present Widespread 1C
Specimen 1C inset: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: oral epithelium Present 1C inset
TS19: oral region mesenchyme Present 1C inset
Specimen 1E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandible primordium Present Widespread 1E
Specimen 1E inset: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present Regionally restricted 1E inset Expressed in both incisor and molar invaginating epithelia.
TS20: mandibular process mesenchyme Present Regionally restricted 1E inset Expression is beginning to fade in the dental mesenchyme.
Specimen 1G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Present 1G
Specimen 1H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Present Regionally restricted 1H No expression at the tip of the molar bud in the area where cells start to stop dividing.
Specimen 1K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw incisor epithelium Strong 1K
Specimen 1L: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: enamel knot Absent 1L
Specimen 1O: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Present 1O
TS25: outer enamel epithelium Present 1O
Specimen 1P: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Strong Regionally restricted 1P Particularly strong expression at the tips of the bell where cells are dividing.
TS25: outer enamel epithelium Strong Regionally restricted 1P Particularly strong expression at the tips of the bell where cells are dividing.
Specimen 2C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch mandibular component Weak 2C
Specimen 3B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component endoderm Present Regionally restricted 3B Expressed in specific epithelium region, exclusive with Bmp4 expression.
Specimen 4A: embryonic day 17.5; Msx2tm1Rilm/Msx2tm1Rilm (more )
Structure Level Pattern Image Note
TS25: lower jaw incisor Ambiguous 4A Expression is dramatically down-regulated.
Specimen 4B: embryonic day 17.5; Msx2tm1Rilm/Msx2tm1Rilm (more )
Structure Level Pattern Image Note
TS25: lower jaw molar Present 4B No overt difference, compared with wild type expression.
Specimen not shown: embryonic day 13.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Present No overt difference, compared with wild type expression.
TS21: lower jaw molar epithelium Present No overt difference, compared with wild type expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory